Across TCGA patient cohorts, TNMD total protein is significantly associated with the go_rna of many other GO terms, with 6,980 significant associations in total. KIRP shows the largest number of these associations.

The most reproducible TNMD-associated GO terms across cancer lineages are Positive regulation of blood vessel remodeling, Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, and Response to cell cycle checkpoint signaling. Each is linked with TNMD in more than 19 cancer types. Because this analysis shows association rather than direction, both TNMD-to-partner and partner-to-TNMD results are reported.

Each partner links to its own Q-omics profile.

total protein associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNMD→partner) and Y-score (partner→TNMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PCPG	Positive regulation of blood vessel remodeling →	-0.120	-1.019	<.001	.001	3	20
STAD	Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis →	-0.059	-0.279	.001	.002	3	19
GBM	Response to cell cycle checkpoint signaling →	+0.038	+0.379	.005	.023	3	18
STAD	Regulation of TRAIL-activated apoptotic signaling pathway →	-0.072	-0.318	<.001	<.001	3	18
PAAD	Negative regulation of extracellular matrix assembly →	-0.117	-0.454	.003	.001	3	18
STAD	Positive regulation of vascular associated smooth muscle cell proliferation →	-0.039	-0.242	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,980 associations by consensus.

Exploration

TNMD survival (RNA) · tumor vs normal (RNA) · all TNMD data types