TNMD

Across TCGA patient cohorts, TNMD mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNMD-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and eEF2. Each is linked with TNMD in more than 2 cancer types. Because this analysis shows association rather than direction, both TNMD-to-partner and partner-to-TNMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TNMD-low versus TNMD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNMD→partner) and Y-score (partner→TNMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.645	+3.019	.015	.019	3	3
UCEC	PCNA →	+0.233	+2.999	.016	.035	3	2
UCEC	eEF2 →	+0.361	+2.999	.025	.035	3	1
UCEC	EGFR_pY1068 →	-0.268	-2.700	.017	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.234	-2.459	.002	.019	3	1
UCEC	MEK1 →	+0.380	+3.459	.021	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by TNMD expression — UCEC

Explore this box plot interactively →