TNMD

Across TCGA cell cohorts, TNMD total protein is significantly associated with the go_rna of many other GO terms, with 6,283 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNMD-associated GO terms across cancer lineages are Regulation of alpha-beta T cell activation, Cellular response to tumor necrosis factor, and T cell migration. Each is linked with TNMD in more than 9 cancer types. Because this analysis shows association rather than direction, both TNMD-to-partner and partner-to-TNMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alpha-beta T cell activation grouped by TNMD-low versus TNMD-high in STOMACH.

total protein associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNMD→partner) and Y-score (partner→TNMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of alpha-beta T cell activation →	-0.056	-0.743	.014	.009	3	10
OESOPHAGUS	Cellular response to tumor necrosis factor →	-0.064	-0.346	.021	.030	2	10
STOMACH	T cell migration →	-0.195	-0.473	.002	.035	3	9
CNS	Formation of extrachromosomal circular DNA →	+0.085	+0.735	<.001	<.001	3	9
URINARY_TRACT	Regulation of protein localization to cell periphery →	-0.070	-0.605	.039	.008	3	9
BONE	Tissue regeneration →	-0.096	-0.996	.017	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,283 associations by consensus.

Regulation of alpha-beta T cell activation by TNMD expression — STOMACH

Explore this box plot interactively →