TNKS1BP1

Across TCGA pan-cancer cohorts, TNKS1BP1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TNKS1BP1 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TNKS1BP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TNKS1BP1 expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, LSCC, and CCRCC are the cancer types where TNKS1BP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.909	.010	78	view →
LSCC	OS	Tertile	II,III,IV	0.627	0.968	.001	18	view →
CCRCC	DFS	Quartile	All	0.550	0.922	.001	16	view →
GBM	DFS	Median	All	0.624	0.801	.007	13	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.872	.010	11	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →
LUAD	OS	Median	III,IV	0.607	0.241	.037	4	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.580	.033	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TNKS1BP1–COAD (DFS)

Open the COAD breakdown →