TNKS1BP1

Across TCGA patient cohorts, TNKS1BP1 mutation is significantly associated with the RNA expression of many other genes, with 5,651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNKS1BP1-associated genes across cancer lineages are ASF1B, CDCA3, and PIMREG. Each is linked with TNKS1BP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TNKS1BP1-to-partner and partner-to-TNKS1BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASF1B grouped by TNKS1BP1-low versus TNKS1BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS1BP1→partner) and Y-score (partner→TNKS1BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASF1B →	+0.719	+2.642	<.001	<.001	3	4
UCEC	CDCA3 →	+0.564	+4.202	<.001	<.001	3	4
UCEC	PIMREG →	+0.968	+3.480	<.001	<.001	3	4
UCEC	CCNB1 →	+0.873	+4.087	<.001	<.001	3	4
UCEC	KIF2C →	+0.743	+2.061	<.001	<.001	3	4
SKCM	CCHCR1 →	+0.350	+1.385	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,651 associations by consensus.

ASF1B by TNKS1BP1 expression — UCEC

Explore this box plot interactively →