TNKS1BP1

Across TCGA patient cohorts, TNKS1BP1 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNKS1BP1-associated genes across cancer lineages are Cyclin-E2, ATM, and Cyclin-B1. Each is linked with TNKS1BP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TNKS1BP1-to-partner and partner-to-TNKS1BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by TNKS1BP1-low versus TNKS1BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS1BP1→partner) and Y-score (partner→TNKS1BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.125	+1.512	.022	.017	3	6
BLCA	ATM →	-0.545	-2.321	.003	.035	3	4
UCEC	Cyclin-B1 →	+0.805	+2.321	<.001	<.001	3	4
UCEC	STAT3_pY705 →	-0.372	-1.765	<.001	.011	3	4
COAD	PCNA →	+0.209	+1.593	.031	.043	3	3
UCEC	eEF2 →	+0.351	+2.807	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Cyclin-E2 by TNKS1BP1 expression — UCEC

Explore this box plot interactively →