TNKS1BP1

Across TCGA cell cohorts, TNKS1BP1 mutation is significantly associated with the RNA expression of many other genes, with 1,049 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNKS1BP1-associated genes across cancer lineages are OR4X2, KIAA1210, and GUCY2D. Each is linked with TNKS1BP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNKS1BP1-to-partner and partner-to-TNKS1BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by TNKS1BP1-low versus TNKS1BP1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS1BP1→partner) and Y-score (partner→TNKS1BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.018	+3.954	<.001	<.001	3	3
PANCREAS	KIAA1210 →	+0.006	+5.000	<.001	.006	3	2
SOFT_TISSUE	GUCY2D →	+0.073	+4.386	<.001	<.001	3	2
LUNG_NSCLC_LUSC	AQP12A →	+0.059	+4.108	<.001	.005	3	2
OVARY	C4orf17 →	+0.039	+3.847	<.001	<.001	3	2
OVARY	CATSPERD →	+0.062	+3.415	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,049 associations by consensus.

OR4X2 by TNKS1BP1 expression — SOFT_TISSUE

Explore this box plot interactively →