TNKS

Across TCGA pan-cancer cohorts, TNKS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TNKS data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TNKS mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TNKS expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where TNKS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.869	0.331	.013	24	view →
UCEC	OS	Median	All	0.979	0.859	.020	10	view →
CCRCC	DFS	Median	II,III,IV	0.704	1.000	.006	7	view →
PDAC	OS	Median	All	0.441	0.666	.027	4	view →
HNSC	DFS	Quartile	IV	1.000	0.747	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TNKS–LUAD (OS)

Open the LUAD breakdown →