TNKS

Across TCGA patient cohorts, TNKS protein abundance is significantly associated with the RNA expression of many other genes, with 4,918 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TNKS-associated genes across cancer lineages are NEIL2, CNOT7, and PXMP2. Each is linked with TNKS in more than 2 cancer types. Because this analysis shows association rather than direction, both TNKS-to-partner and partner-to-TNKS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNKS versus NEIL2 in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS→partner) and Y-score (partner→TNKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEIL2 →	+0.639	+0.308	.003	.002	3	3
BRCA	CNOT7 →	+0.421	+0.250	.008	.002	3	3
HNSC	PXMP2 →	+0.811	+0.639	.002	<.001	3	3
UCEC	SAMM50 →	+0.448	+0.251	.003	.004	3	3
LSCC	PBK →	+1.165	+0.323	<.001	<.001	3	2
BRCA	UBQLNL →	-0.459	-0.301	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,918 associations by consensus.

TNKS vs NEIL2 — BRCA

Explore this scatter interactively →