TNKS

Across TCGA cell cohorts, TNKS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,785 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNKS-associated GO terms across cancer lineages are Negative regulation of sister chromatid cohesion, Positive regulation of telomere capping, and Peptidyl-serine phosphorylation. Each is linked with TNKS in more than 17 cancer types. Because this analysis shows association rather than direction, both TNKS-to-partner and partner-to-TNKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of sister chromatid cohesion grouped by TNKS-low versus TNKS-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS→partner) and Y-score (partner→TNKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of sister chromatid cohesion →	+0.177	+1.055	<.001	<.001	3	18
SKIN	Positive regulation of telomere capping →	+0.130	+1.014	<.001	<.001	3	18
KIDNEY	Peptidyl-serine phosphorylation →	+0.102	+1.021	<.001	<.001	3	18
KIDNEY	Peptidyl-serine modification →	+0.100	+0.973	<.001	<.001	3	18
URINARY_TRACT	Protein localization to chromosome, telomeric region →	+0.128	+0.987	<.001	.001	3	17
SOFT_TISSUE	RNA destabilization →	+0.074	+1.049	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,785 associations by consensus.

Negative regulation of sister chromatid cohesion by TNKS expression — LUNG_SCLC

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