TNKS

Across TCGA cell cohorts, TNKS mutation is significantly associated with the RNA expression of many other genes, with 535 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNKS-associated genes across cancer lineages are SOX8, ADAM30, and GOLGA6C. Each is linked with TNKS in more than 1 cancer types. Because this analysis shows association rather than direction, both TNKS-to-partner and partner-to-TNKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX8 grouped by TNKS-low versus TNKS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS→partner) and Y-score (partner→TNKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SOX8 →	+1.042	+2.215	<.001	.003	3	2
SKIN	ADAM30 →	+0.045	+3.217	.001	.006	3	1
SKIN	GOLGA6C →	+0.062	+3.113	.003	.004	3	1
SKIN	H3-4 →	+0.143	+3.722	.008	.002	3	1
SKIN	ZPBP2 →	+0.014	+3.217	.001	.006	3	1
SKIN	MUC21 →	+0.021	+3.523	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 535 associations by consensus.

SOX8 by TNKS expression — LARGE_INTESTINE

Explore this box plot interactively →