TNKS

Across TCGA cell cohorts, TNKS mutation is significantly associated with the mutation status of many other genes, with 3,739 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNKS-associated genes across cancer lineages are RHOT2, XIRP2, and CIT. Each is linked with TNKS in more than 4 cancer types. Because this analysis shows association rather than direction, both TNKS-to-partner and partner-to-TNKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RHOT2 grouped by TNKS-low versus TNKS-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNKS→partner) and Y-score (partner→TNKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RHOT2 →	+4.467	+3.240	.004	.004	1	5
BLOOD_Leukemia	XIRP2 →	+2.466	+3.281	.001	.001	1	5
BLOOD_Lymphoma	CIT →	+4.584	+4.584	.007	.007	1	5
LARGE_INTESTINE	MAGI1 →	+1.925	+2.169	.001	.001	1	5
BREAST	RASGRF1 →	+4.297	+4.857	.009	.009	1	4
BREAST	KDM5A →	+5.297	+5.297	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,739 associations by consensus.

RHOT2 by TNKS expression — OVARY

Explore this box plot interactively →