TNK2

Across TCGA pan-cancer cohorts, TNK2 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TNK2 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher TNK2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TNK2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

THYM, UCEC, and MESO are the cancer types where TNK2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	II,III,IV	1.000	0.436	.011	28	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
LIHC	DFS	Median	All	0.225	0.557	.029	6	view →
BLCA	OS	Median	III,IV	0.090	0.582	<.001	6	view →
SKCM	OS	Median	All	0.142	0.344	.025	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SARC	DFS	Median	All	0.179	0.594	.031	3	view →
STAD	DFS	Median	III,IV	0.836	0.337	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TNK2–THYM (OS)

Open the THYM breakdown →