TNK2

Across TCGA patient cohorts, TNK2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNK2-associated genes across cancer lineages are P-Cadherin, c-Kit, and eEF2. Each is linked with TNK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNK2-to-partner and partner-to-TNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-Cadherin grouped by TNK2-low versus TNK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNK2→partner) and Y-score (partner→TNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	P-Cadherin →	-0.139	-2.415	.001	.002	3	3
UCEC	c-Kit →	-0.172	-1.584	.013	.002	3	3
UCEC	eEF2 →	+0.275	+1.184	.010	.022	3	2
UCEC	A-Raf_pS299 →	-0.132	-2.807	<.001	<.001	3	2
UCEC	GAPDH →	+0.425	+1.925	.007	.004	3	2
UCEC	MSH6 →	-0.298	-1.415	.002	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

P-Cadherin by TNK2 expression — UCEC

Explore this box plot interactively →