TNK2

Across TCGA cell cohorts, TNK2 mutation is significantly associated with the RNA expression of many other genes, with 611 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNK2-associated genes across cancer lineages are DPEP2NB, WDR36, and ZCCHC2. Each is linked with TNK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNK2-to-partner and partner-to-TNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPEP2NB grouped by TNK2-low versus TNK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNK2→partner) and Y-score (partner→TNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DPEP2NB →	+0.050	+3.273	<.001	.003	3	2
LARGE_INTESTINE	WDR36 →	+0.547	+2.584	.003	.002	3	2
LARGE_INTESTINE	ZCCHC2 →	+0.930	+2.526	<.001	.002	3	2
LARGE_INTESTINE	SPATA2L →	+0.549	+3.523	.001	<.001	3	2
LARGE_INTESTINE	DDX21 →	+0.552	+2.523	.005	.003	3	2
LARGE_INTESTINE	RAB26 →	+0.969	+1.850	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 611 associations by consensus.

DPEP2NB by TNK2 expression — BLOOD_Leukemia

Explore this box plot interactively →