TNK1

Across TCGA pan-cancer cohorts, TNK1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TNK1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TNK1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TNK1 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

LSCC, COAD, and HNSC are the cancer types where TNK1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNK1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	All	+0.241	<.001	7	view →
COAD	All	III,IV	−0.525	.011	4	view →
HNSC	Male	All	+0.141	.011	4	view →
CCRCC	Female	All	+0.195	.011	3	view →
PDAC	Female	II,III,IV	−0.553	.007	2	view →
LUAD	All	All	−0.127	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TNK1–LSCC

Open the LSCC breakdown →