TNIP2

Across TCGA pan-cancer cohorts, TNIP2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TNIP2 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TNIP2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TNIP2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where TNIP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.914	0.784	.013	29	view →
PDAC	DFS	Tertile	III,IV	0.697	0.213	.001	23	view →
LSCC	DFS	Median	All	0.612	0.832	.014	16	view →
UCEC	DFS	Quartile	All	0.958	0.710	.010	14	view →
CCRCC	DFS	Quartile	All	0.319	1.000	.012	6	view →
GBM	OS	Median	All	0.289	0.499	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TNIP2–HNSC (OS)

Open the HNSC breakdown →