TNIK

Across TCGA patient cohorts, TNIK protein abundance is significantly associated with the RNA expression of many other genes, with 11,639 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TNIK-associated genes across cancer lineages are MIR569, IQGAP2, and DDAH1. Each is linked with TNIK in more than 7 cancer types. Because this analysis shows association rather than direction, both TNIK-to-partner and partner-to-TNIK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNIK versus MIR569 in UCEC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNIK→partner) and Y-score (partner→TNIK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR569 →	+0.988	+0.446	<.001	<.001	3	8
BRCA	IQGAP2 →	+1.485	+0.467	<.001	<.001	3	5
LSCC	DDAH1 →	+0.521	+0.410	.005	<.001	3	5
OV	DPYD →	+1.281	+0.677	.002	.008	3	5
LUAD	LRRC31 →	+1.473	+0.302	.003	.006	3	4
BRCA	ARHGAP26 →	+0.595	+0.597	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,639 associations by consensus.

TNIK vs MIR569 — UCEC

Explore this scatter interactively →