TNIK

Across TCGA patient cohorts, TNIK mutation is significantly associated with the RNA expression of many other genes, with 5,328 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNIK-associated genes across cancer lineages are MAP2K1, ETFA, and NIPA1. Each is linked with TNIK in more than 4 cancer types. Because this analysis shows association rather than direction, both TNIK-to-partner and partner-to-TNIK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP2K1 grouped by TNIK-low versus TNIK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNIK→partner) and Y-score (partner→TNIK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP2K1 →	+0.450	+1.291	<.001	<.001	3	5
UCEC	ETFA →	+0.513	+1.874	<.001	<.001	3	4
UCEC	NIPA1 →	+0.719	+1.673	<.001	<.001	3	4
UCEC	DIABLO →	+0.248	+1.037	.005	.007	3	4
SKCM	CHUK →	+0.425	+2.028	.001	.001	3	4
HNSC	ZNF800 →	+0.496	+3.345	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,328 associations by consensus.

MAP2K1 by TNIK expression — UCEC

Explore this box plot interactively →