TNIK

Across TCGA cell cohorts, TNIK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,694 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TNIK-associated GO terms across cancer lineages are Positive regulation of leukocyte differentiation, Positive regulation of hemopoiesis, and Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration. Each is linked with TNIK in more than 9 cancer types. Because this analysis shows association rather than direction, both TNIK-to-partner and partner-to-TNIK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of leukocyte differentiation grouped by TNIK-low versus TNIK-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNIK→partner) and Y-score (partner→TNIK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of leukocyte differentiation →	+0.041	+0.828	<.001	.005	3	9
CNS	Positive regulation of hemopoiesis →	+0.041	+0.828	<.001	.005	3	9
LIVER	Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration →	+0.141	+1.921	.002	.007	3	9
BLOOD_Leukemia	Positive regulation of receptor recycling →	+0.087	+1.290	<.001	<.001	3	9
LARGE_INTESTINE	Negative regulation of inflammatory response to antigenic stimulus →	+0.075	+0.850	.001	.009	2	10
PANCREAS	Regulation of microvillus organization →	+0.101	+1.214	.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,694 associations by consensus.

Positive regulation of leukocyte differentiation by TNIK expression — CNS

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