TNIK

Across TCGA cell cohorts, TNIK mutation is significantly associated with the RNA expression of many other genes, with 1,394 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNIK-associated genes across cancer lineages are OR2M4, CEP76, and INTS2. Each is linked with TNIK in more than 1 cancer types. Because this analysis shows association rather than direction, both TNIK-to-partner and partner-to-TNIK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M4 grouped by TNIK-low versus TNIK-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNIK→partner) and Y-score (partner→TNIK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR2M4 →	+0.020	+4.614	<.001	.004	3	2
SKIN	CEP76 →	+0.424	+3.364	.004	.002	3	2
SKIN	INTS2 →	+0.532	+3.067	.004	.009	3	2
LARGE_INTESTINE	UBE3A →	+0.618	+3.459	<.001	.001	3	2
LARGE_INTESTINE	DNAJC16 →	+0.650	+3.459	<.001	.001	3	2
LARGE_INTESTINE	PPAT →	+0.661	+2.936	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,394 associations by consensus.

OR2M4 by TNIK expression — PANCREAS

Explore this box plot interactively →