TNFSF9

Across TCGA patient cohorts, TNFSF9 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFSF9-associated genes across cancer lineages are Lck, VHL, and 14-3-3_beta. Each is linked with TNFSF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF9-to-partner and partner-to-TNFSF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by TNFSF9-low versus TNFSF9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF9→partner) and Y-score (partner→TNFSF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.310	+3.169	.004	.020	3	1
UCEC	VHL →	-1.252	-3.169	<.001	.020	2	1
UCEC	14-3-3_beta →	-0.113	-3.156	.041	.020	1	1
UCEC	JNK2 →	+0.276	+3.169	.011	.020	1	1
UCEC	p62 Lck ligand →	+0.388	+3.169	.029	.020	1	1
UCEC	Chk2_pT68 →	-0.201	-3.169	.049	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Lck by TNFSF9 expression — UCEC

Explore this box plot interactively →