TNFSF14

Across TCGA patient cohorts, TNFSF14 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFSF14-associated genes across cancer lineages are Akt_pS473, Akt_pT308, and Rictor_pT1135. Each is linked with TNFSF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF14-to-partner and partner-to-TNFSF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pS473 grouped by TNFSF14-low versus TNFSF14-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF14→partner) and Y-score (partner→TNFSF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Akt_pS473 →	-0.512	-1.906	.018	.016	3	1
SKCM	Akt_pT308 →	-0.402	-1.861	.044	.049	3	1
SKCM	Rictor_pT1135 →	-0.124	-1.889	.045	.016	3	1
SKCM	Chk1 →	+0.205	+2.713	.007	.003	3	1
SKCM	4E-BP1_pT70 →	-0.143	-2.321	.047	.033	3	1
UCEC	14-3-3_beta →	-0.122	-3.143	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Akt_pS473 by TNFSF14 expression — SKCM

Explore this box plot interactively →