TNFSF13B

Across TCGA pan-cancer cohorts, TNFSF13B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TNFSF13B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNFSF13B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFSF13B is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where TNFSF13B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFSF13B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+2.607	<.001	12	view →
HNSC	All	III,IV	+0.846	<.001	10	view →
KIRP	Male	All	+1.202	<.001	7	view →
STAD	All	II,III,IV	+1.130	<.001	6	view →
BRCA	All	All	+0.862	<.001	6	view →
LUSC	Male	All	−0.988	<.001	5	view →
THCA	All	All	−0.465	.013	2	view →
ESCA	All	All	+1.436	.016	1	view →
CHOL	All	All	+1.253	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TNFSF13B–KIRC

Open the KIRC breakdown →