TNFSF13

Across TCGA patient cohorts, TNFSF13 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFSF13-associated genes across cancer lineages are Bax, Caspase-8, and JNK_pT183_Y185. Each is linked with TNFSF13 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF13-to-partner and partner-to-TNFSF13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by TNFSF13-low versus TNFSF13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF13→partner) and Y-score (partner→TNFSF13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.360	+3.000	.009	.037	3	1
UCEC	Caspase-8 →	-0.305	-3.000	.035	.037	3	1
UCEC	JNK_pT183_Y185 →	-0.284	-2.986	.003	.037	2	1
UCEC	JNK2 →	+0.307	+3.000	.007	.037	1	1
UCEC	Myosin-IIa →	+0.211	+3.007	.049	.019	1	1
UCEC	p70-S6K →	+0.240	+3.026	.031	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Bax by TNFSF13 expression — UCEC

Explore this box plot interactively →