TNFSF12

Across TCGA pan-cancer cohorts, TNFSF12 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TNFSF12 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TNFSF12 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNFSF12 expression acts as an unfavorable survival marker.

GBM and LUAD are the cancer types where TNFSF12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.634	0.896	.021	12	view →
LUAD	OS	Median	II,III,IV	0.763	1.000	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TNFSF12–GBM (OS)

Open the GBM breakdown →