TNFSF12-TNFSF13

Across TCGA pan-cancer cohorts, TNFSF12-TNFSF13 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TNFSF12-TNFSF13 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TNFSF12-TNFSF13 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TNFSF12-TNFSF13 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, ACC, and MESO are the cancer types where TNFSF12-TNFSF13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	III,IV	0.748	0.528	.002	54	view →
ACC	OS	Quartile	II,III,IV	0.185	0.611	<.001	50	view →
MESO	DFS	Tertile	IV	0.245	0.651	.011	48	view →
LGG	DFS	Median	All	0.315	0.478	<.001	40	view →
LIHC	OS	Median	III,IV	0.456	0.710	.008	27	view →
HNSC	DFS	Tertile	IV	0.464	0.225	.013	14	view →
CESC	DFS	Median	III,IV	0.234	0.600	.014	12	view →
UCS	OS	Quartile	All	0.437	0.740	.013	12	view →
GBM	DFS	Tertile	All	0.173	0.374	.005	9	view →
SKCM	DFS	Tertile	IV	0.169	0.785	.015	9	view →
THCA	OS	Quartile	II,III,IV	0.941	1.000	.016	9	view →
PAAD	DFS	Median	II,III,IV	0.347	0.203	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TNFSF12-TNFSF13–KIRC (DFS)

Open the KIRC breakdown →