TNFSF11

Across TCGA pan-cancer cohorts, TNFSF11 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TNFSF11 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TNFSF11 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TNFSF11 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, UCEC, and LIHC are the cancer types where TNFSF11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.171	0.750	.002	16	view →
UCEC	DFS	Median	All	0.959	0.625	.021	14	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TNFSF11–LUAD (OS)

Open the LUAD breakdown →