TNFSF11

Across TCGA patient cohorts, TNFSF11 protein abundance is significantly associated with the RNA expression of many other genes, with 1,793 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TNFSF11-associated genes across cancer lineages are YPEL1, UPK3A, and TCFL5. Each is linked with TNFSF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFSF11-to-partner and partner-to-TNFSF11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNFSF11 versus YPEL1 in LUAD, with a Pearson correlation of -0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF11→partner) and Y-score (partner→TNFSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	YPEL1 →	-0.786	-1.516	.008	.006	3	1
LUAD	UPK3A →	-1.465	-1.475	<.001	<.001	3	1
LUAD	TCFL5 →	-0.869	-1.648	.002	.003	3	1
LUAD	OXT →	-1.444	-1.261	.005	.005	3	1
LUAD	BPI →	+0.201	+1.247	.002	.006	3	1
LUAD	PRPS2 →	-0.878	-0.857	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,793 associations by consensus.

TNFSF11 vs YPEL1 — LUAD

Explore this scatter interactively →