TNFSF11

Across TCGA patient cohorts, TNFSF11 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFSF11-associated genes across cancer lineages are ASNS, EGFR_pY1068, and FASN. Each is linked with TNFSF11 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFSF11-to-partner and partner-to-TNFSF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TNFSF11-low versus TNFSF11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF11→partner) and Y-score (partner→TNFSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.769	+2.815	<.001	.036	3	3
UCEC	EGFR_pY1068 →	-0.255	-1.678	.008	.023	3	2
COAD	FASN →	+0.566	+2.815	.008	.036	3	2
UCEC	MEK1 →	+0.432	+2.087	.002	.005	3	2
UCEC	PDCD4 →	-0.659	-3.700	<.001	.001	3	2
UCEC	Annexin-1 →	+0.599	+2.019	.002	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ASNS by TNFSF11 expression — COAD

Explore this box plot interactively →