TNFSF11

Across TCGA cell cohorts, TNFSF11 RNA expression is significantly associated with the go_rna of many other GO terms, with 853 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible TNFSF11-associated GO terms across cancer lineages are Regulation of corticotropin-releasing hormone secretion, Response to molecule of bacterial origin, and Skin development. Each is linked with TNFSF11 in more than 7 cancer types. Because this analysis shows association rather than direction, both TNFSF11-to-partner and partner-to-TNFSF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of corticotropin-releasing hormone secretion grouped by TNFSF11-low versus TNFSF11-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFSF11→partner) and Y-score (partner→TNFSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of corticotropin-releasing hormone secretion →	+0.494	+0.798	<.001	<.001	3	8
PANCREAS	Response to molecule of bacterial origin →	+0.046	+0.664	.002	.001	3	6
PANCREAS	Skin development →	+0.109	+1.171	<.001	<.001	3	5
PANCREAS	3'-UTR-mediated mRNA destabilization →	+0.099	+0.808	.001	.002	3	5
BREAST	Epidermis development →	+0.129	+0.278	<.001	.007	3	5
LUNG_SCLC	Sodium ion homeostasis →	+0.150	+0.279	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 853 associations by consensus.

Regulation of corticotropin-releasing hormone secretion by TNFSF11 expression — PANCREAS

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