TNFSF10

Across TCGA pan-cancer cohorts, TNFSF10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TNFSF10 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TNFSF10 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNFSF10 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where TNFSF10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.597	0.891	.008	5	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →
LUAD	OS	Quartile	II,III,IV	0.228	0.688	.033	2	view →
CCRCC	OS	Median	All	0.708	0.921	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TNFSF10–LSCC (OS)

Open the LSCC breakdown →