TNFRSF9

Across TCGA patient cohorts, TNFRSF9 mutation is significantly associated with the RNA expression of many other genes, with 763 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF9-associated genes across cancer lineages are OR6L2P, METTL22, and RNU6-1320P. Each is linked with TNFRSF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF9-to-partner and partner-to-TNFRSF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6L2P grouped by TNFRSF9-low versus TNFRSF9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF9→partner) and Y-score (partner→TNFRSF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR6L2P →	+0.104	+2.744	<.001	.005	3	2
UCEC	METTL22 →	+0.361	+3.740	<.001	<.001	3	2
BLCA	RNU6-1320P →	+0.303	+7.640	<.001	.009	3	2
UCEC	DHODH →	+0.395	+2.917	.002	.001	3	2
UCEC	PROSER1 →	+0.536	+3.332	.002	.005	3	2
UCEC	TUBGCP4 →	+0.632	+3.732	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 763 associations by consensus.

OR6L2P by TNFRSF9 expression — SKCM

Explore this box plot interactively →