TNFRSF9

Across TCGA patient cohorts, TNFRSF9 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF9-associated genes across cancer lineages are FoxM1, Gab2, and INPP4B. Each is linked with TNFRSF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF9-to-partner and partner-to-TNFRSF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TNFRSF9-low versus TNFRSF9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF9→partner) and Y-score (partner→TNFRSF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.262	+2.222	.016	.011	3	1
UCEC	Gab2 →	+0.356	+1.700	.018	.044	3	1
UCEC	INPP4B →	-0.387	-2.584	.004	.010	3	1
UCEC	JNK2 →	+0.211	+1.700	.012	.044	3	1
UCEC	Ku80 →	+0.218	+2.235	.029	.006	3	1
UCEC	MSH2 →	-0.214	-3.143	.028	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

FoxM1 by TNFRSF9 expression — UCEC

Explore this box plot interactively →