TNFRSF9

Across TCGA cell cohorts, TNFRSF9 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNFRSF9-associated genes across cancer lineages are FAM205A, IL2, and NLRP8. Each is linked with TNFRSF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF9-to-partner and partner-to-TNFRSF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205A grouped by TNFRSF9-low versus TNFRSF9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF9→partner) and Y-score (partner→TNFRSF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.034	+4.614	<.001	.002	3	1
SKIN	IL2 →	+0.022	+5.415	<.001	.004	3	1
SKIN	NLRP8 →	+0.026	+4.977	<.001	.007	3	1
BLOOD_Leukemia	USP26 →	+0.036	+5.201	<.001	.006	3	1
BLOOD_Leukemia	PRSS38 →	+0.205	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MGAT4D →	+0.021	+4.922	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FAM205A by TNFRSF9 expression — LARGE_INTESTINE

Explore this box plot interactively →