Across TCGA patient cohorts, TNFRSF4 mutation is significantly associated with the RNA expression of many other genes, with 287 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF4-associated genes across cancer lineages are RNA5SP288, IGLV3-15, and RN7SKP186. Each is linked with TNFRSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF4-to-partner and partner-to-TNFRSF4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF4→partner) and Y-score (partner→TNFRSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNA5SP288 →	+0.394	+5.033	<.001	.009	3	2
LIHC	IGLV3-15 →	+0.192	+5.544	.001	.004	3	2
COAD	RN7SKP186 →	+1.004	+4.962	<.001	.003	3	2
COAD	PRR23A →	+0.152	+4.962	<.001	.003	3	2
COAD	ZNF736P6Y →	+0.137	+6.568	<.001	<.001	3	2
LIHC	BUB1P1 →	+0.074	+5.447	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 287 associations by consensus.

Exploration

TNFRSF4 survival (RNA) · tumor vs normal (RNA) · all TNFRSF4 data types