Across TCGA patient cohorts, TNFRSF4 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF4-associated genes across cancer lineages are PDK1_pS241, AMPK_pT172, and p70-S6K. Each is linked with TNFRSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF4-to-partner and partner-to-TNFRSF4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF4→partner) and Y-score (partner→TNFRSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.259	+2.820	.013	.036	3	1
UCEC	AMPK_pT172 →	+0.521	+2.820	.038	.036	3	1
UCEC	p70-S6K →	+0.251	+2.833	.033	.035	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

TNFRSF4 survival (RNA) · tumor vs normal (RNA) · all TNFRSF4 data types