Across TCGA cell cohorts, TNFRSF4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNFRSF4-associated genes across cancer lineages are IFNA4, MS4A18, and PNMA6F. Each is linked with TNFRSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF4-to-partner and partner-to-TNFRSF4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF4→partner) and Y-score (partner→TNFRSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNA4 →	+0.024	+4.922	.009	.009	3	1
LARGE_INTESTINE	MS4A18 →	+0.028	+4.095	<.001	.009	3	1
LARGE_INTESTINE	PNMA6F →	+0.004	+4.415	<.001	.007	3	1
LARGE_INTESTINE	F11 →	+0.073	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

TNFRSF4 survival (RNA) · tumor vs normal (RNA) · all TNFRSF4 data types