Across TCGA patient cohorts, TNFRSF25 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF25-associated genes across cancer lineages are Rad50, FoxM1, and FOXO3a_pS318_S321. Each is linked with TNFRSF25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF25-to-partner and partner-to-TNFRSF25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF25→partner) and Y-score (partner→TNFRSF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.424	-3.308	<.001	.009	3	2
UCEC	FoxM1 →	+0.282	+3.331	.008	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.169	-1.990	<.001	.030	3	1
UCEC	GATA6 →	-0.139	-2.985	.034	.034	3	1
UCEC	MEK1 →	+0.342	+2.000	.023	.030	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.420	-2.459	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

TNFRSF25 survival (RNA) · tumor vs normal (RNA) · all TNFRSF25 data types