Across TCGA cell cohorts, TNFRSF25 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNFRSF25-associated genes across cancer lineages are CYP4A11, OR4D2, and MROH5. Each is linked with TNFRSF25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF25-to-partner and partner-to-TNFRSF25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF25→partner) and Y-score (partner→TNFRSF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CYP4A11 →	+0.006	+4.807	<.001	.006	3	2
BLOOD_Myeloma	OR4D2 →	+0.013	+4.807	<.001	.006	3	2
LARGE_INTESTINE	MROH5 →	+0.064	+2.560	.003	.008	3	2
BLOOD_Myeloma	CLEC2A →	+0.733	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	ZNRF4 →	+0.012	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	CCL21 →	+0.094	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

TNFRSF25 survival (RNA) · tumor vs normal (RNA) · all TNFRSF25 data types