TNFRSF1B

Across TCGA cell cohorts, TNFRSF1B mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNFRSF1B-associated genes across cancer lineages are C20orf85, GATA5, and USP29. Each is linked with TNFRSF1B in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF1B-to-partner and partner-to-TNFRSF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by TNFRSF1B-low versus TNFRSF1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF1B→partner) and Y-score (partner→TNFRSF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.032	+5.969	<.001	.001	3	2
BLOOD_Lymphoma	GATA5 →	+0.006	+4.191	.009	.007	3	1
BLOOD_Leukemia	USP29 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	TAAR6 →	+0.018	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IQCF5 →	+0.052	+5.201	.007	.006	3	1
BLOOD_Leukemia	ADAM7 →	+0.052	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C20orf85 by TNFRSF1B expression — BLOOD_Leukemia

Explore this box plot interactively →