TNFRSF1A

Across TCGA pan-cancer cohorts, TNFRSF1A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TNFRSF1A data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TNFRSF1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TNFRSF1A expression acts as an unfavorable survival marker, although some lineages such as LIHC show a favorable association.

UVM, UCEC, and LIHC are the cancer types where TNFRSF1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.292	0.674	.035	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	DFS	Median	III,IV	1.000	0.153	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TNFRSF1A–UVM (OS)

Open the UVM breakdown →