TNFRSF1A

Across TCGA pan-cancer cohorts, TNFRSF1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TNFRSF1A data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TNFRSF1A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNFRSF1A expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where TNFRSF1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.297	0.876	<.001	52	view →
LSCC	OS	Quartile	All	0.717	1.000	<.001	45	view →
LUAD	DFS	Median	All	0.416	0.766	.001	35	view →
HNSC	OS	Quartile	III,IV	0.935	0.585	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TNFRSF1A–PDAC (OS)

Open the PDAC breakdown →