Across TCGA pan-cancer cohorts, TNFRSF18 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TNFRSF18 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TNFRSF18 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNFRSF18 expression acts as an unfavorable survival marker.

LUAD, LSCC, and HNSC are the cancer types where TNFRSF18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.475	1.000	.013	10	view →
LSCC	DFS	Quartile	All	0.609	0.892	.047	2	view →
HNSC	DFS	Median	II,III,IV	0.857	1.000	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TNFRSF18 tumor-vs-normal RNA expression · all TNFRSF18 data types