TNFRSF17

Across TCGA patient cohorts, TNFRSF17 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF17-associated genes across cancer lineages are ATM, C-Raf, and JNK2. Each is linked with TNFRSF17 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF17-to-partner and partner-to-TNFRSF17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TNFRSF17-low versus TNFRSF17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF17→partner) and Y-score (partner→TNFRSF17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.730	-3.169	<.001	.019	3	2
UCEC	C-Raf →	+0.225	+3.169	.001	.019	3	2
UCEC	JNK2 →	+0.269	+2.459	.005	.020	3	1
UCEC	MEK1 →	+0.410	+2.459	.020	.020	3	1
UCEC	Notch1 →	+0.228	+3.013	<.001	.018	3	1
UCEC	PCNA →	+0.313	+3.584	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ATM by TNFRSF17 expression — UCEC

Explore this box plot interactively →