TNFRSF14

Across TCGA pan-cancer cohorts, TNFRSF14 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TNFRSF14 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TNFRSF14 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNFRSF14 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where TNFRSF14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.568	0.928	.001	15	view →
PDAC	DFS	Tertile	All	0.781	0.407	.007	10	view →
CCRCC	OS	Tertile	III,IV	0.771	0.357	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TNFRSF14–LSCC (OS)

Open the LSCC breakdown →