TNFRSF14

Across TCGA patient cohorts, TNFRSF14 protein abundance is significantly associated with the RNA expression of many other genes, with 10,610 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TNFRSF14-associated genes across cancer lineages are TRAJ45, DBN1, and IDO1. Each is linked with TNFRSF14 in more than 3 cancer types. Because this analysis shows association rather than direction, both TNFRSF14-to-partner and partner-to-TNFRSF14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNFRSF14 versus TRAJ45 in HNSC, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF14→partner) and Y-score (partner→TNFRSF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAJ45 →	+3.028	+0.660	.004	.002	3	4
CCRCC	DBN1 →	-0.697	-0.388	<.001	.002	3	4
HNSC	IDO1 →	+2.886	+0.660	<.001	.002	3	3
HNSC	SIT1 →	+1.700	+0.660	.006	.002	3	3
HNSC	CD3G →	+1.808	+0.660	.005	.002	3	3
HNSC	GBP2 →	+1.841	+0.660	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,610 associations by consensus.

TNFRSF14 vs TRAJ45 — HNSC

Explore this scatter interactively →