TNFRSF14

Across TCGA patient cohorts, TNFRSF14 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF14-associated genes across cancer lineages are JNK2, Ku80, and Notch1. Each is linked with TNFRSF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF14-to-partner and partner-to-TNFRSF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TNFRSF14-low versus TNFRSF14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF14→partner) and Y-score (partner→TNFRSF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.159	+2.834	.042	.034	3	1
UCEC	Ku80 →	+0.266	+2.472	.004	.010	3	1
UCEC	Notch1 →	+0.170	+2.472	.002	.010	3	1
UCEC	Rad50 →	-0.212	-2.986	.025	.035	3	1
UCEC	Caspase-8 →	-0.201	-3.432	.042	.005	3	1
UCEC	Cyclin-B1 →	+0.578	+3.321	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK2 by TNFRSF14 expression — UCEC

Explore this box plot interactively →