TNFRSF14

Across TCGA cell cohorts, TNFRSF14 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,779 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TNFRSF14-associated GO terms across cancer lineages are Regulation of tolerance induction dependent upon immune response, Negative regulation of T cell cytokine production, and Negative regulation of cytokine production involved in immune response. Each is linked with TNFRSF14 in more than 19 cancer types. Because this analysis shows association rather than direction, both TNFRSF14-to-partner and partner-to-TNFRSF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of tolerance induction dependent upon immune response grouped by TNFRSF14-low versus TNFRSF14-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF14→partner) and Y-score (partner→TNFRSF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of tolerance induction dependent upon immune response →	+1.947	+3.233	<.001	<.001	3	20
SOFT_TISSUE	Negative regulation of T cell cytokine production →	+1.394	+2.076	<.001	<.001	3	17
LIVER	Negative regulation of cytokine production involved in immune response →	+0.283	+2.493	.005	.003	2	17
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic pattern recognition receptor signaling pathway →	+0.108	+1.994	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Intracellular receptor signaling pathway →	+0.068	+1.977	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of cytokine-mediated signaling pathway →	+0.075	+1.841	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,779 associations by consensus.

Regulation of tolerance induction dependent upon immune response by TNFRSF14 expression — KIDNEY

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