TNFRSF14

Across TCGA cell cohorts, TNFRSF14 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNFRSF14-associated genes across cancer lineages are H1-1, GABRA6, and SPEM3. Each is linked with TNFRSF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF14-to-partner and partner-to-TNFRSF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H1-1 grouped by TNFRSF14-low versus TNFRSF14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF14→partner) and Y-score (partner→TNFRSF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	H1-1 →	+0.103	+4.054	<.001	.004	3	1
LARGE_INTESTINE	GABRA6 →	+0.447	+3.930	<.001	.003	3	1
LARGE_INTESTINE	SPEM3 →	+0.016	+4.347	<.001	.001	3	1
BLOOD_Lymphoma	WIPF3 →	+0.110	+4.672	<.001	<.001	3	1
BLOOD_Lymphoma	ABCG8 →	+0.014	+3.606	.001	.002	3	1
BLOOD_Lymphoma	ARGFX →	+0.038	+3.584	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

H1-1 by TNFRSF14 expression — LARGE_INTESTINE

Explore this box plot interactively →